The initial years Guntur Medical College had a humble beginning in the 1940s. The then Government of Madras issued an order on June 22, 1946 that Guntur Medical College would start functioning from July1, 1946 admitting 50 students. The help rendered by Mrs. Achanta Rukmini Lakshmipathi, the then Health Minister was immense and all those who receive their education in this great institution are really indebted to her. Dr. G.V.Satynarayana Murthy took charge as the Special Officer, GMC Scheme on september 17, 1946.
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The students of the first few batches who joined GMC were really variegated. Some were Andhra; some were Tamilians and a few Malayalis and Kannadigas. Women’s hostel was established in September 1946. A rented building in 3rd line Brodiepet was made the men’s hostel. Dr.D.Jagannatha Reddy took charge as the Principal on July 26, 1954.The Pathology block, constructed in front of the Physiology Block, housed the paraclinical branches, administrative section and lecture galleries. The excellent Pathology Museum is still considered one of the best in the country. Clinical courses were started by Sri T.Prakasam, the then Chief Minister. The clinical departments located in the new General Hospital were established on modern lines. Dr. M.Munuswamy, Professor of Surgery , was the first Superintendent.